Focus on Molecules: Platelet-derived growth factor C, PDGF-C
نویسندگان
چکیده
منابع مشابه
Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression.
The PDGF (platelet-derived growth factor) family members are potent mitogens for cells of mesenchymal origin and serve as important regulators of cell migration, survival, apoptosis and transformation. Tumour-derived PDGF ligands are thought to function in both autocrine and paracrine manners, activating receptors on tumour and surrounding stromal cells. PDGF-C and -D are secreted as latent dim...
متن کاملPlatelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure.
Platelet-derived growth factor (PDGF)-C is a novel member of the PDGF family that binds to PDGF alphaalpha and alphabeta receptors. The growth factor domain of PDGF-C (GFD-PDGF-C) was expressed in high yields in Escherichia coli and was purified and refolded from inclusion bodies obtaining a biologically active growth factor with dimeric structure. The GFD-PDGF-C contains 12 cysteine residues, ...
متن کاملNovel insight into a platelet-derived growth factor-C/Smad3 axis in liver fibrosis. Focus on "Role of Smad3 in platelet-derived growth factor-C-induced liver fibrosis".
LIVER FIBROSIS IS THE COMMON RESPONSE to chronic liver injury and is due to the abnormal accumulation of extracellular matrix (ECM). In response to injury, activated hepatic stellate cells (HSCs) proliferate and produce excess amounts of ECM in response to inflammatory cytokines and growth factors (1, 2, 7). Among these mediators, transforming growth factor(TGF) is the major profibrogenic cytok...
متن کاملNovel insight into a Platelet-Derived Growth Factor-C/Smad3
1 axis in liver fibrosis 2 3 4 Wonhyo Seo and Won-Il Jeong 5 6 7 Laboratory of Liver Research, Graduate School of Medical Science and Engineering, 8 KAIST, Daejeon, Republic of Korea 9 10 11 12 Corresponding Author: 13 Won-Il Jeong, DVM, Ph.D 14 Laboratory of Liver Research, 15 Bldg E7 Rm8107, GSMSE/KAIST, 16 291 Daehak-ro, Yuseong-gu, Daejeon 34191, 17 Republic of Korea 18 Tel: 82-42-350-4239 ...
متن کاملLabel-free aptasensor for platelet-derived growth factor (PDGF) protein.
A label-free aptasensor for platelet-derived growth factor (PDGF) protein is reported. The aptasensor uses mixed self-assembled monolayers (SAMs) composed of a thiol-modified PDGF binding aptamer and 6-mercaptohexanol (MCH) on a gold electrode. The SAMs were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) before an...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2008
ISSN: 0014-4835
DOI: 10.1016/j.exer.2007.08.007